GK061 ScienCell 人類DNA損傷感應(yīng)qPCR檢測試劑盒,Human DNA Damage Sensing qPCR Array Kit

ScienCell 研究實(shí)驗(yàn)室（ScienCell）是一家生物技術(shù)公司，其使命是實(shí)驗(yàn)和治療用細(xì)胞和細(xì)胞相關(guān)產(chǎn)品的研究和發(fā)展。 ScienCell為研究界提供各種高質(zhì)量的正常的人類和動(dòng)物細(xì)胞，細(xì)胞培養(yǎng)基和試劑，培養(yǎng)基添加因子，細(xì)胞來源的RNA，cDNA和蛋白質(zhì)。ScienCell的科學(xué)家們以改善生活質(zhì)量，實(shí)現(xiàn)細(xì)胞的能力，打擊人類退化性疾病為目的研究和開發(fā)各種細(xì)胞治療策略。ScienCell總部設(shè)在美國加利福尼亞州圣地亞哥，公司成立于1999年。

北京諾博萊德作為ScienCell品牌的經(jīng)銷商，為客戶提供，正規(guī)進(jìn)口，貨期穩(wěn)定，折扣好的服務(wù)標(biāo)準(zhǔn)。

GK061 ScienCell人類DNA損傷感應(yīng)qPCR檢測試劑盒，Human DNA Damage Sensing qPCR Array Kit，產(chǎn)品簡介：

產(chǎn)品品牌: ScienCell

產(chǎn)品貨號(hào)：GK061

產(chǎn)品名稱：GK061 ScienCell人類DNA損傷感應(yīng)qPCR檢測試劑盒，Human DNA Damage Sensing qPCR Array Kit

產(chǎn)品規(guī)格：One 96-well plate, one 20ul reaction per well

GK061 ScienCell人類DNA損傷感應(yīng)qPCR檢測試劑盒，Human DNA Damage Sensing qPCR Array Kit， 產(chǎn)品說明：

ScienCell的GeneQuery™人類DNA損傷傳感qPCR陣列試劑盒（GQH-DDS）旨在促進(jìn)參與DNA損傷傳感的40個(gè)關(guān)鍵基因的基因表達(dá)譜分析。DNA損傷，如突變、斷裂、交聯(lián)、缺失/插入和易位，由于內(nèi)部和外部壓力而不斷產(chǎn)生。必須實(shí)施適當(dāng)?shù)?span>DNA損傷反應(yīng)以維持基因組穩(wěn)定性。下面顯示了如何對(duì)所包含的基因進(jìn)行分組的簡要示例：

DNA損傷傳感器：ATM，ATR，PRKDC，PARP1

細(xì)胞周期調(diào)控： CHEK1， CHEK2， CCNB1， CCNB2， CCNB3， CCND1， CCND2， CCND3， CCNE2， CDK2， CDK4， CDK6

ATM 信號(hào)通路： ABL1， BRCA1， CDC25A， CDKN1A， CHEK1， CHEK2， GADD45A， RAD51， RBBP8， TP53

ATR 信號(hào)通路： CDC25A， CDC25C， CDK2， CHEK1， CHEK2， HUS1， MDM2， RAD1， RAD17， RAD9A， TP53

細(xì)胞凋亡： ABL1， ATM， BAX， BRCA1， CASP3， CASP9， CDKN1A， CHEK2， PRKDC， RAD91， TP53

GeneQuery™ qPCR 芯片試劑盒采用 96 孔板格式的 qPCR 就緒，每個(gè)孔包含一個(gè)引物組，可以特異性識(shí)別并有效擴(kuò)增靶基因的 cDNA。精心設(shè)計(jì)的引物確保：（i）qPCR分析中的優(yōu)良退火溫度為65°C（含2 mM Mg2+，不含DMSO）;（ii）除非另有說明，否則引物組可識(shí)別靶基因的所有已知轉(zhuǎn)錄本變體;（iii）只有一個(gè)基因被擴(kuò)增。每個(gè)引物組都已通過qPCR和熔解曲線分析和凝膠電泳進(jìn)行了驗(yàn)證。

ScienCell's GeneQuery™ Human DNA Damage Sensing qPCR Array Kit (GQH-DDS) is designed to facilitate gene expression profiling of 40 key genes involved in DNA damage sensing. DNA damages, such as mutations, breaks, cross-links, deletions/insertions and translocations, are constantly generated due to internal and external stresses. Appropriate DNA damage responses must be implemented to maintain genome stability. Brief examples of how included genes may be grouped are shown below:

·         DNA damage sensors: ATM, ATR, PRKDC, PARP1

·         Cell cycle regulation: CHEK1, CHEK2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE2, CDK2, CDK4, CDK6

·         ATM signaling pathway: ABL1, BRCA1, CDC25A, CDKN1A, CHEK1, CHEK2, GADD45A, RAD51, RBBP8, TP53

·         ATR signaling pathway: CDC25A, CDC25C, CDK2, CHEK1, CHEK2, HUS1, MDM2, RAD1, RAD17, RAD9A, TP53

·         Apoptosis: ABL1, ATM, BAX, BRCA1, CASP3, CASP9, CDKN1A, CHEK2, PRKDC, RAD91, TP53

GeneQuery™ qPCR array kits are qPCR ready in a 96-well plate format, with each well containing one primer set that can specifically recognize and efficiently amplify a target gene's cDNA. The carefully designed primers ensure that: (i) the optimal annealing temperature in qPCR analysis is 65°C (with 2 mM Mg²⁺, and no DMSO); (ii) the primer set recognizes all known transcript variants of target gene, unless otherwise indicated; and (iii) only one gene is amplified. Each primer set has been validated by qPCR with melt curve analysis, and gel electrophoresis.

基因查詢™人類 DNA 損傷傳感 qPCR 陣列板布局*（8 個(gè)粗體和斜體控件）

提示：基因選擇可能會(huì)根據(jù)新的研究和開發(fā)進(jìn)行更新

ScienCell基因表達(dá)分析產(chǎn)品訂購信息：

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GK010   人類黑素細(xì)胞發(fā)育和色素沉著qPCR檢測試劑盒，Human Melanocyte Development & Pigmentation qPCR Array Kit

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GK017   人血管生成qPCR檢測試劑盒，Human Angiogenesis qPCR Array Kit

GK018   人內(nèi)皮細(xì)胞表型異質(zhì)性qPCR檢測試劑盒，Human Endothelial Cell Phenotypic Heterogeneity qPCR Array Kit

GK019   人內(nèi)皮細(xì)胞生物學(xué)qPCR檢測試劑盒，Human Endothelial Cell Biology qPCR Array Kit

GK020   人B細(xì)胞受體信號(hào)通路qPCR檢測試劑盒，Human B Cell Receptor Signaling Pathway qPCR Array Kit

GK021   人類T細(xì)胞受體信號(hào)通路qPCR檢測試劑盒，Human T Cell Receptor Signaling Pathway qPCR Array Kit

GK022   人內(nèi)吞作用qPCR檢測試劑盒，Human Endocytosis qPCR Array Kit

GK023   人皮內(nèi)細(xì)胞分化qPCR檢測試劑盒，Human Endothelial Cell Differentiation qPCR Array Kit

GK024   人體剪切應(yīng)力和機(jī)械傳導(dǎo)qPCR檢測試劑盒，Human Shear Stress and Mechanotransduction qPCR Array Kit

GK025   人類Notch信號(hào)通路qPCR檢測試劑盒，uman Notch Signaling Pathway qPCR Array Kit

GK026   人類Wnt信號(hào)通路qPCR檢測試劑盒，Human Wnt Signaling Pathway qPCR Array Kit

GK027   人類非經(jīng)典Wnt信號(hào)通路qPCR檢測試劑盒，Human Noncanonical Wnt Signaling Pathways qPCR Array Kit

GK028   人類Wnt信號(hào)靶基因qPCR檢測試劑盒，Human Wnt Signaling Target Genes qPCR Array Kit

GK029   Human Tie2/Angpt信號(hào)qPCR檢測試劑盒，Human Tie2/Angpt Signaling qPCR Array Kit

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GK072   人類適應(yīng)性免疫反應(yīng)qPCR檢測試劑盒，Human Adaptive Immune Response qPCR Array Kit

GK073   人類小膠質(zhì)細(xì)胞Sensome qPCR檢測試劑盒，Human Microglial Sensome qPCR Array Kit

GK074   人角質(zhì)細(xì)胞生物學(xué)qPCR檢測試劑盒，Human Keratocyte Biology qPCR Array

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GK090   人體細(xì)胞連接qPCR檢測試劑盒，Human Cell Junctions qPCR Array Kit

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GK092   人胰腺星狀細(xì)胞生物學(xué)qPCR檢測試劑盒，Human Pancreatic Stellate Cell Biology qPCR Array Kit

GK093   Human Renal Mesangial Cell Biology qPCR Array Kit，Human Renal Mesangial Cell Biology qPCR Array Kit

GK094   Human Mesenchymal Stem Cell Differentiation qPCR Array，Human Mesenchymal Stem Cell Differentiation qPCR Array Kit

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GK097   人類平滑肌細(xì)胞生物學(xué)qPCR檢測試劑盒，Human Smooth Muscle Cell Biology qPCR Array Kit

GK098   人類心臟肌細(xì)胞生物學(xué)qPCR檢測試劑盒，Human Cardiac Myocyte Biology qPCR Array Kit

GK099   人類骨骼肌細(xì)胞生物學(xué)qPCR檢測試劑盒，Human Skeletal Muscle Cell Biology qPCR Array Kit

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